Research Interests: Vertebrate
Development and Developmental Toxicology
Dr. Reddy's research focus is on the mechanisms
of pathogenesis of developmental defects
(especially cleft palate) by mycotoxins
(e.g., secalonic acid D) and other chemicals
to which human beings and animals are exposed.
Dr. Reddy's interests also include the elucidation
of toxic effects of environmental chemicals
on animal reproduction.
Cleft Palate is the most common developmental
abnormality both in human beings and animals.
A mouse model and embryonic palatal mesenchymal
cells of mouse and human origin are being
utilized to investigate the effect of chemicals
on various palatal signaling mechanisms
(including those of growth factors and other
extracellular ligands) involved in the synthesis
of extracellular matrix components, apoptosis
and cell proliferation. Effect of chemicals
on palatal protein kinases (PKA, PKC and
Cyclin Dependent Kinases) and cell cycle
genes are the focus of current studies aimed
at understanding their roles in normal palate
development and in abnormal palate development
following chemical exposure. Ultimate goal
is to develop gene modulation approaches
relevant to the prevention of chemical-induced
developmental defects (cleft palate) even
in the face of their continuing exposure.
Balasubramanian G and Reddy CS: Novel Mechanism
of Protein Kinase C Inhibition Involving
the Pseudosubstrate Region by Secalonic
Acid D. Toxicol Appl Pharmacol, 163: 86-93,
Balasubramanian G Hanumegowda U and Reddy
CS: Secalonic acid D alters the nature and
inhibits the binding of the transcription
factors to the phorbol 12-O-tetradecanoate-13-acetate
(TPA)-response element in the developing
murine secondary palate. Toxicol Appl Pharmacol,
169: 142-150, 2000.
Umesh H Balasubramanian G and Reddy CS:
Secalonic acid D alters the phosphorylation
of transcription factors and their binding
to cAMP response element in developing murine
secondary palate. J. Craniofac.Genet. Dev.
Biol., 20:173-182, 2001.
Hanumegowda U Dhulipala VC and Reddy CS:
Mechanism of Secalonic acid D-induced inhibition
of transcription factor binding to cyclic
AMP response element in developing murine
palate, Toxicol Sci, , 70:55-62, 2002.
Dhulipala VC, Hanumegowda UM, Balasubramanian
G and Reddy CS: Relevance of the palatal
protein kinase A pathway to the pathogenesis
of cleft palate by secalonic acid D in mice,
Toxicol Appl Pharmacol, 194:270-279, 2004.
Dhulipala, V. C., Welshons, W. V. and Reddy,
C. S.: Inhibition of Human Embryonic Palatal
Mesenchymal Cell Cycle by Secalonic Acid
D: A Probable Mechanism of Its Cleft Palate
Induction, Orthodont. Craniofac. Res., 7:227-236,