Frank W. Booth, PhD

Email: BoothF@missouri.edu

Research Interests: Physiological, biochemical, molecular and genetic adaptations to altered usage of skeletal muscle.

Dr. Booth is interested in the determining how exercise signals are sensed, transduced, and effect the expression of genes in skeletal muscle. To this end, multiple animal models of exercise and physical inactivity are employed. The end point of such investigations is to provide on the molecular level of evidence-based medicine for why sedentary lifestyle increases the risk of many unhealthy conditions. Skeletal muscle affects the health of other organs (heart, adipose tissue, brain, etc.) by altering insulin resistance, blood hypertriglycidemia, blood HDL levels, and neuro-integrative pathways. Thus, all molecular events to decreased contractile activity must be integrated into models of how inactive skeletal muscle diminishes the expression of putative "health" genes.

Selected Publications:
Pattison, JS, Folk LC, Madsen RW, Childs TE, Booth FW. Transcriptional profiling identifies extensive down regulation of extracellular matrix gene expression in old atrophying rat soleus muscle. Physiol Genomics. 2003 Sep 29;15(1):34-43.

Pattison, JS, Folk LC, Madsen RW, Booth FW. Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy. J Appl Physiol. 95:2171-2179, 2003.

Pattison, JS, Folk LC, Madsen RW, Childs TE, Spangenburg EE, Booth FW. 2003. Expression profiling identifies dysregulation of myosin heavy chains IIb & IIx during mechanical unloading in soleus muscles of old rats. J Physiol. 553:357-368, 2003.

Morris RT, Spangenburg EE, Booth FW. Responsiveness of Cell Signaling Pathways During the Failed Regrowth of Aged Skeletal Muscle. Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle. J Appl Physiol. 96:398-404, 2004.

Spangenburg, EE, Bowles, DK, Booth, FW. IGF-I-induced transcriptional activity of the skeletal muscle alpha-actin gene is regulated by signaling mechanisms linked to voltage-gated calcium channels during myoblast differentiation. Endocrinology. 145:2054-2063, 2004.

Machida S, Booth, FW. Increased nuclear proteins in muscle satellite cells in aged animals as compared to young growing animals. Exp Geront. 39:1521-1525, 2004.